The Tuckasegee River (variant spellings include Tuckaseegee and Tuckaseigee), flows entirely within two counties in western North Carolina. It begins its course in Jackson County in the “Sky Island” biome at the confluence of Panthertown and Greenland creeks. It flows in a northwesterly direction into Swain County, where it is joined by the Oconaluftee River (the Tuckasegee’s largest tributary draining a significant land mass in The Great Smoky Mountains National Park), It then winds through Whittier northwest to Bryson City, NC. Bryson City developed along both sides of the river around this area. The river enters Fontana Lake just downstream of Bryson City, and ultimately flows as a tributary into the Little Tennessee River.